Freeman Spogli Institute for International Studies Program on Energy and Sustainable Development Stanford University


Hurry Up and Wait: The Effect of Delays in Diagnosis and Treatment on Survival in Patients with Non-small-cell Lung Cancer  
CHP/PCOR Research in Progress Seminar

Date and Time
August 3, 2005
1:30 PM - 3:00 PM

Open to the public
No RSVP required

Purpose: Prior studies of the effect of wait time on survival in patients with non-small-cell lung cancer (NSCLC) yielded results that were mixed and confounded by multiple sources of bias. We aimed to describe variation in wait times, identify predictors of longer wait times, and examine the effect of wait time on survival.

Methods: We performed a retrospective cohort study by reviewing the records of consecutive patients who were diagnosed with NSCLC between 1/1/02 and 12/31/03 at VA Palo Alto Health Care System. We used multivariable statistical methods to identify independent predictors of longer wait times, and to examine the effect of wait time on survival.

Results: We identified 129 veterans with NSCLC (mean age 67 years, 98% men, 83% white), most with adenocarcinoma (51%) or squamous cell carcinoma (30%). A minority (18%) presented with a solitary pulmonary nodule (SPN). Median time from initial suspicion to treatment was 85 days (range 3 to 1355 days). Independent predictors of longer wait times (>90 days) were hospitalization within 7 days of initial suspicion (OR 6.0, 95% CI 2.2 to 16.2), tumor size >3 cm (OR 5.4, CI 2.1 to 14.1), chest x-ray findings other than the primary tumor (OR 2.6, CI 0.9 to 7.5), and any symptom (OR 2.5, CI 1.0 to 6.0). In multivariable analysis, wait time was not associated with survival (HR 1.5, CI 0.9 to 2.5). In patients with SPN, there was a trend toward improved survival when wait time was <90 days (figure).

Conclusions: Wait times for patients with NSCLC were often longer than recommended. Patients with more severe presentations of NSCLC have shorter wait times, confounding the relationship between wait time and survival. Our results suggest the hypothesis that in patients with malignant SPN, survival may be better in patients treated within 90 days.

Clinical Implications: If confirmed, our results suggest that quality improvement efforts should focus on reducing wait times in patients with solitary nodules and others with potentially resectable NSCLC.

CHP/PCOR Conference Room
117 Encina Commons, Room 119
Stanford University
Stanford, CA 94305
» Directions/Map

FSI Contact
Sara Selis